Novel heat exchanger in extracorporeal circuit: technical and biological feasibility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085912" target="_blank" >RIV/00023001:_____/25:00085912 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/25:10504397
Result on the web
<a href="https://www.nature.com/articles/s41598-025-20798-w#Fun" target="_blank" >https://www.nature.com/articles/s41598-025-20798-w#Fun</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-20798-w" target="_blank" >10.1038/s41598-025-20798-w</a>
Alternative languages
Result language
angličtina
Original language name
Novel heat exchanger in extracorporeal circuit: technical and biological feasibility
Original language description
To evaluate a novel anticoagulation strategy in an extracorporeal circuit, we introduce a device that induces local hypothermia as blood flows through the circuit. Using a pig model, we assessed its technical feasibility, biocompatibility, and safety. Sixteen pigs were randomly assigned to either the cooled group or the control group and underwent midline laparotomy to establish extracorporeal circulation (blood flow 500 ml/min) via the caudal vena cava for up to four hours. Blood samples were collected at baseline and at 15, 60, and 240 min during the experiment. In the cooled group, blood was cooled to 20 degrees C and then rewarmed to 37 degrees C, while in the control group, blood was maintained at 37 degrees C. A total of 6 cooled and 4 control pigs completed 4 h of the experiment. Our findings confirm the technical feasibility of the proposed device, which effectively maintained the required temperature differentials while keeping the pressure differentials in the circuit within 150 mmHg. No issues with circuit patency were observed. Additionally, no adverse effects were detected on erythrocyte stability. Within the limitation of the short observation period, no adverse effects were observed on renal, liver, or cardiac function. Our data suggest that local hypothermia in the extracorporeal circuit may mitigate surgery-induced inflammation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10700 - Other natural sciences
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
"art. no. 36864"
UT code for WoS article
001600059400011
EID of the result in the Scopus database
2-s2.0-105019540054