An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023272%3A_____%2F22%3A10135558" target="_blank" >RIV/00023272:_____/22:10135558 - isvavai.cz</a>
Result on the web
<a href="https://www.pnas.org/doi/10.1073/pnas.2106743119" target="_blank" >https://www.pnas.org/doi/10.1073/pnas.2106743119</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.2106743119" target="_blank" >10.1073/pnas.2106743119</a>
Alternative languages
Result language
angličtina
Original language name
An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers
Original language description
Human culture, biology, and health were shaped dramatically by the onset of agriculture similar to 12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared "predicted" genetic contributions to height from paleogenomic data and "achieved" adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (similar to 38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of 23.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and 22.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals 22.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
60102 - Archaeology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
1091-6490
e-ISSN
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Volume of the periodical
119
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000819867000005
EID of the result in the Scopus database
999