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An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023272%3A_____%2F22%3A10135558" target="_blank" >RIV/00023272:_____/22:10135558 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.pnas.org/doi/10.1073/pnas.2106743119" target="_blank" >https://www.pnas.org/doi/10.1073/pnas.2106743119</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1073/pnas.2106743119" target="_blank" >10.1073/pnas.2106743119</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

  • Original language description

    Human culture, biology, and health were shaped dramatically by the onset of agriculture similar to 12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared &quot;predicted&quot; genetic contributions to height from paleogenomic data and &quot;achieved&quot; adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (similar to 38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of 23.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and 22.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals 22.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    60102 - Archaeology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Proceedings of the National Academy of Sciences of the United States of America

  • ISSN

    1091-6490

  • e-ISSN

  • Volume of the periodical

    119

  • Issue of the periodical within the volume

    15

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    1-12

  • UT code for WoS article

    000819867000005

  • EID of the result in the Scopus database

    999