Are antibiotics a risk factor for the development of necrotizing enterocolitis - case-control retrospective study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F19%3AN0000016" target="_blank" >RIV/00023698:_____/19:N0000016 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43918255
Result on the web
<a href="https://doi.org/10.1007/s00431-019-03373-0" target="_blank" >https://doi.org/10.1007/s00431-019-03373-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00431-019-03373-0" target="_blank" >10.1007/s00431-019-03373-0</a>
Alternative languages
Result language
angličtina
Original language name
Are antibiotics a risk factor for the development of necrotizing enterocolitis - case-control retrospective study
Original language description
Previous studies have identified numerous risk factors associated with necrotizing enterocolitis (NEC) in very low birth weight (VLBW; birth weight less than 1500g) infants. One of the potential pathophysiological contributors could be antibiotic therapy. Our aim was to explore the association between antibiotic exposure and NEC in VLBW infants. We designed a retrospective 1:2 case-control cohort study in a level III neonatal intensive care unit. Our study group composed of VLBW infants born between January 2012 and December 2014 with a diagnosis of NEC stage IIA or greater (Bell's modified criteria). Our intent was to match every case in the study group to two controls. Our primary outcome was an association between antibiotic exposure and NEC. Twenty-two cases of NEC were matched to 32 controls. The infants who developed NEC were exposed to a statistically significantly more frequent number of antibiotic courses and to more days on any antibiotic prior to the development of NEC. There were significant differences between cases and controls with respect to the duration of exposure to gentamicin and meropenem specifically.Conclusion: The data from our study demonstrate that prolonged exposure to antibiotic therapy is associated with an increased risk of NEC among VLBW infants. Furthermore, gentamicin and meropenem, but not other antibiotics, had a significant association with the incidence of NEC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pediatrics
ISSN
0340-6199
e-ISSN
1432-1076
Volume of the periodical
178
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
923-928
UT code for WoS article
000467651900015
EID of the result in the Scopus database
2-s2.0-85064514434