Extremely low birthweight neonates with phenylketonuria require special dietary management
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F21%3AN0000013" target="_blank" >RIV/00023698:_____/21:N0000013 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10429502 RIV/65269705:_____/21:00075607 RIV/00064203:_____/21:10429502 RIV/00064165:_____/21:10429502 RIV/00216224:14110/21:00122006
Result on the web
<a href="https://doi.org/10.1111/apa.16035" target="_blank" >https://doi.org/10.1111/apa.16035</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apa.16035" target="_blank" >10.1111/apa.16035</a>
Alternative languages
Result language
angličtina
Original language name
Extremely low birthweight neonates with phenylketonuria require special dietary management
Original language description
Aim Extremely low birthweight (ELBW) neonates require a high protein intake, but this can be challenging in the very rare cases when they also have phenylketonuria (PKU). This is due to a lack of suitable parenteral nutrition or enteral formula. Our aim was to analyse tolerance to phenylalanine in these infants. Material There are approximately 110 000 children born in the Czech Republic each year. A neonatal screening programme from 2005 to 2020 found that 320 neonates had PKU, including 30 premature neonates with a birth weight of less than 2500 g. Results This study focused on three neonates who were born with ELBWs of 720, 740 and 950 g, respectively. Phenylalanine levels normalised in ELBW neonates with PKU within 1 week of the introduction of low-phenylalanine parenteral or enteral nutrition. The tolerance to phenylalanine was very high (70-110 mg/kg) in the first months of life, due to a rapid weight gain, but significantly decreased during infancy. Conclusion Extremely low birthweight neonates with PKU need special dietary management. Regular assessments of phenylalanine are necessary during the first weeks of life to allow prompt dietary adjustments that reflect rapid weight gain and transitory high tolerance to phenylalanine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACTA PAEDIATRICA
ISSN
0803-5253
e-ISSN
1651-2227
Volume of the periodical
110
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
2994-2999
UT code for WoS article
000678910800001
EID of the result in the Scopus database
2-s2.0-85111444405