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Is breastfeeding in MS harmful or not? An answer from real-world Czech data.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F23%3AN0000011" target="_blank" >RIV/00023698:_____/23:N0000011 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/23:00133298 RIV/61988987:17110/23:A2402NOO RIV/00216208:11130/23:10465272 RIV/00216208:11110/23:10465272 and 14 more

  • Result on the web

    <a href="https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(23)00292-4" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(23)00292-4</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.msard.2023.104790" target="_blank" >10.1016/j.msard.2023.104790</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Is breastfeeding in MS harmful or not? An answer from real-world Czech data.

  • Original language description

    Introduction: The influence of breastfeeding and it & PRIME;s duration on the course of multiple sclerosis (MS) is unclear. Here we analyzed a real-world data for breastfeeding women with MS and their disease course collected from a Czech national registry ReMuS.Objectives: To identify risk factors associated with not initiating breastfeeding after delivery, to analyze the impact of breastfeeding on the MS disease course, evaluate the assumption, that breastfeeding is not harmful in MS patients, and compare the disease course by breastfeeding status.Materials and methods: Using propensity score matching we compared Expanded Disability Status Scale (EDSS), confirmed disease worsening (CDW) and annual relapse rate (ARR) in breastfeeding and non-breastfeeding MS patients according to disease duration, disease modifying treatment (DMT) before pregnancy, last EDSS score before conception, age, and ARR during pregnancy. We also compared these parameters between breastfeeding patients not using a DMT and non-breastfeeding patients who resumed DMT within 3 months after delivery. EDSS, ARR, and CDW were collected at 12, 24, and 36 months after delivery.Results: A total of 1681 pregnancies that ended in delivery were analyzed from 2013 through 2020. Change in ARR and EDSS values and 6-months CDW did not significantly differ between the analyzed groups. Compared with non-breastfeeding women who resumed DMT early after delivery, breastfeeding women with MS did not experience worse clinical outcomes even without initiating a DMT. Discussion: Breastfeeding in Czech women with MS did not negatively affect the disease course and can be supported. Patients with MS can be treated with certain DMTs alongside breastfeeding and there is no need to stop breastfeeding, if the patient is clinically stable.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30210 - Clinical neurology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    MULTIPLE SCLEROSIS AND RELATED DISORDERS

  • ISSN

    2211-0348

  • e-ISSN

    2211-0356

  • Volume of the periodical

    76

  • Issue of the periodical within the volume

    AUG 2023

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    104790

  • UT code for WoS article

    001032690900001

  • EID of the result in the Scopus database

    2-s2.0-85162249781