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Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F23%3AN0000045" target="_blank" >RIV/00023698:_____/23:N0000045 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/23:00133385 RIV/61988987:17110/23:A2402O0X RIV/47813059:19510/23:A0000489 RIV/70883521:28150/23:63565958 and 2 more

  • Result on the web

    <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439625/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439625/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s12957-023-03147-x" target="_blank" >10.1186/s12957-023-03147-x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Ideal marker for targeted axillary dissection (IMTAD): a prospective multicentre trial

  • Original language description

    BackgroundTargeted axillary dissection (TAD) is an established method for axillary staging in patients with breast cancer after neoadjuvant chemotherapy (NAC). TAD consists of sentinel lymph node biopsy and initially pathological lymph node excision, which must be marked by a reliable marker before NAC.MethodsThe IMTAD study is a prospective multicentre trial comparing three localisation markers for lymph node localisation (clip + iodine seed, magnetic seed, carbon suspension) facilitating subsequent surgical excision in the form of TAD. The primary outcome was to prospectively compare the reliability, accuracy, and safety according to complication rate during marker implantation and detection and marker dislodgement.ResultsOne hundred eighty-nine patients were included in the study-in 135 patients clip + iodine seed was used, in 30 patients magnetic seed and in 24 patients carbon suspension. The complication rate during the marker implantation and detection were not statistically significant between individual markers (p = 0.263; p = 0.117). Marker dislodgement was reported in 4 patients with clip + iodine seed localisation (3.0%), dislodgement did not occur in other localisation methods (p = 0.999). The false-negativity of sentinel lymph node (SLN) was observed in 8 patients, the false-negativity of targeted lymph nodes (TLN) wasn & PRIME;t observed at all, the false-negativity rate (FNR) from the subcohort of ypN + patients for SLN is 9.6% and for TLN 0.0%.ConclusionThe IMTAD study indicated, that clip + iodine seed, magnetic seed and carbon suspension are statistically comparable in terms of complications during marker implantation and detection and marker dislodgement proving their safety, accuracy, and reliability in TAD. The study confirmed, that the FNR of the TLN was lower than the FNR of the SLN proving that the TLN is a better marker for axillary lymph node status after NAC

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    WORLD JOURNAL OF SURGICAL ONCOLOGY

  • ISSN

    1477-7819

  • e-ISSN

    1477-7819

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    252

  • UT code for WoS article

    001049914600002

  • EID of the result in the Scopus database

    2-s2.0-85168357403