Dynamics of serum levels and reference ranges of copeptin in the 3rd trimester of pregnancy in healthy pregnant women with uncomplicated pregnancy and delivery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F24%3AN0000038" target="_blank" >RIV/00023698:_____/24:N0000038 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/24:43926967 RIV/61989592:15110/24:73627610 RIV/00098892:_____/24:10158661

Result on the web

<a href="https://doi.org/10.48095/cccg202489" target="_blank" >https://doi.org/10.48095/cccg202489</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccg202489" target="_blank" >10.48095/cccg202489</a>

Result language

angličtina

Original language name

Dynamics of serum levels and reference ranges of copeptin in the 3rd trimester of pregnancy in healthy pregnant women with uncomplicated pregnancy and delivery

Original language description

Objective: Copeptin is a stable fragment of vasopressin. Copeptin levels have been found to reflect the degree of endothelial stress in various conditions, including acute coronary syndrome. Copeptin may be a bio marker for endothelial stress during pregnancy. However, there is still a lack of understanding of its dynamics and levels throughout pregnancy. This study aims to describe intra-individual and longitudinal changes in copeptin levels at 30(th) and 36(th) gestational weeks in healthy pregnant women with uncomplicated pregnancy and delivery and to establish specific reference ranges. Methods: A total of 125 pregnant women with uncomplicated pregnancy and delivery were included. These women were monitored throughout their pregnancy and gave birth at the Department of Obstetrics and Gynecology Olomouc University Hospital. The blood was taken at similar to 30 and similar to 36 gestational weeks. Serum copeptin levels were measured using a Kryptor Compact PLUS analyzer. For statistics, we used R software and the "referenceRanges" package. Results: It was found that serum levels of copeptin were significantly higher in the 36(th) week group than in the 30(th) week group (P < 0.05). Cook's distance was used to eliminate outliers. The 30(th) week median was 3.377 pmol/ l, reference range = 1.343-7.829 pmol/ l, and the 36 week was median 4.735 pmol/ l and reference range = 2.06-13.2 pmol/ l. In the 36(th) week reference range, the median was higher than in healthy, non-pregnant women (P < 0.05). Copeptin values can exceed 10 pmol/ l, particularly after the 36(th) week. In the 3(rd) trimester, this value may indicate cardiovascular and endothelial overload. Conclusion: Copeptin levels were found to vary significantly depending on gestational week. The proposed reference ranges take into account the increased secretion of vasopressin in pregnancy. The existence of specific upper reference limits represents a potential advantage in detecting pregnant women prone to hypertensive disease in the 3(rd) trimester.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY

ISSN

1210-7832

e-ISSN

1805-4455

Volume of the periodical

89

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

89-94

UT code for WoS article

001313102100001

EID of the result in the Scopus database

2-s2.0-85192326844