High protein intake can lead to serious hypophosphatemia and hypokalemia in growth restricted preterm newborns

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F24%3AN0000048" target="_blank" >RIV/00023698:_____/24:N0000048 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/24:43926318

Result on the web

<a href="https://doi.org/10.1002/jpr3.12029" target="_blank" >https://doi.org/10.1002/jpr3.12029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jpr3.12029" target="_blank" >10.1002/jpr3.12029</a>

Result language

angličtina

Original language name

High protein intake can lead to serious hypophosphatemia and hypokalemia in growth restricted preterm newborns

Original language description

Objectives High protein parenteral nutrition (HPPN) in the early postnatal period is a recommended strategy for very low birth weight (VLBW) infants. However, limited data is available on electrolyte changes when HPPN strategy is utilized. We investigated the impact of HPPN on the development of hypophosphatemia and hypokalemia in preterm VLBW newborns. Methods A retrospective, single-center study investigated the levels of phosphate and potassium in VLBW infants who received HPPN (amino acids intake up to 3.5 g/kg/day) during the first week of life. Preterm infants were divided into two subgroups: appropriate for gestational age (AGA) and small for gestational age (SGA) newborns. Clinical data were obtained from hospital database and medical records. Results Overall, 170 VLBW infants were included for the study analysis: 41 SGA (mean birth weight 752 +- 39 g) and 129 AGA infants (mean birth weight 994 +- 23 g). Phosphate and potassium levels were significantly lower in the SGA infants compared to AGA infants (Phosphate: 0.97 +- 0.07 mmol/l vs. 1.44 +- 0.04 mmol/l, p < 0.001; Potassium: 3.0 +- 0.1 mmol/l vs. 3.6 +- 0.1 mmol/l, p < 0.001). Conclusions Repeated measurement of serum phosphate and potassium is recommended when HPPN strategy is utilized in preterm SGA infants where significant hypophosphatemia and hypokalemia might have serious clinical consequences.

Czech name

—

Czech description

—

Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

—

OECD FORD branch

30209 - Paediatrics

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JPGN Reports

ISSN

2691-171X

e-ISSN

2691-171X

Volume of the periodical

5

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

58-65

UT code for WoS article

—

EID of the result in the Scopus database

—