Medically assisted reproduction significantly affects the expression of microRNA associated with adverse obstetric outcomes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F25%3AN0000008" target="_blank" >RIV/00023698:_____/25:N0000008 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928999
Result on the web
<a href="https://doi.org/10.1016/j.rbmo.2025.105130" target="_blank" >https://doi.org/10.1016/j.rbmo.2025.105130</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rbmo.2025.105130" target="_blank" >10.1016/j.rbmo.2025.105130</a>
Alternative languages
Result language
angličtina
Original language name
Medically assisted reproduction significantly affects the expression of microRNA associated with adverse obstetric outcomes
Original language description
Research question: Do normal term pregnancies conceived by medically assisted reproduction (MAR) differ in the expression of microRNA associated with adverse obstetric outcomes compared with normal term pregnancies after natural conception, and are there differences in microRNA expression profiles between MAR groups? Design: This retrospective case-control study examined 103 pregnancies conceived by MAR and 79 pregnancies conceived naturally. The expression of 29 microRNA associated with adverse obstetric outcomes was evaluated in maternal peripheral blood leukocytes collected at 10-13 weeks of gestation. Results: Pregnancies after MAR showed significant changes in expression of 4-9 microRNA depending on the specific MAR group (IVF/intracytoplasmic sperm injection [ICSI] fresh embryo transfer group, 9 microRNA; intrauterine insemination group, 6 microRNA; IVF/ICSI frozen embryo transfer group, 4 microRNA) compared with pregnancies after natural conception in the early stages of pregnancy. Remarkably, some of these changes overlapped with those found in the early stages of pregnancies with a subsequent occurrence of pre-eclampsia, HELLP syndrome, fetal growth restriction, small for gestational age, gestational diabetes, preterm delivery without other pregnancy complications, miscarriage or stillbirth. Conclusions: This study is the first to show that even normal term pregnancies after MAR show significantly altered microRNA expression profiles in the first trimester of gestation compared with pregnancies after natural conception. The degree of dysregulation in microRNA expression varied depending on the MAR used, and the observed changes were partially consistent with those found in pregnancies that later developed pregnancy-related complications. These findings suggest that MAR significantly affects the epigenetic profile.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
REPRODUCTIVE BIOMEDICINE ONLINE
ISSN
1472-6483
e-ISSN
1472-6491
Volume of the periodical
51
Issue of the periodical within the volume
6
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
15
Pages from-to
105130
UT code for WoS article
001610701700001
EID of the result in the Scopus database
2-s2.0-105020093404