Safety Profile of Meloxicam: Analysis of Adverse Event Reports in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F25%3AN0000016" target="_blank" >RIV/00023698:_____/25:N0000016 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/25:10503883 RIV/00064165:_____/25:10503883

Result on the web

<a href="https://www.nel.edu/safety-profile-of-meloxicam-analysis-of-adverse-event-reports-in-the-czech-republic-3017/" target="_blank" >https://www.nel.edu/safety-profile-of-meloxicam-analysis-of-adverse-event-reports-in-the-czech-republic-3017/</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Safety Profile of Meloxicam: Analysis of Adverse Event Reports in the Czech Republic

Original language description

INTRODUCTION: Meloxicam is a preferential cyclooxygenase-2 inhibitor widely prescribed for rheumatic diseases. Given its long clinical use, further assessment of its safety profile remains relevant. AIM OF STUDY: This study aimed to evaluate the safety profile of meloxicam in the Czech Republic using national pharmacovigilance data, and to compare reported adverse events (AEs) with findings from the WHO VigiAccess database. METHODS: We analyzed all meloxicam-related AEs reported to the State Institute for Drug Control (SUKL) between January 2015 and December 2020, as well as related data extracted from the World Health Organization's pharmacovigilance VigiAccess database. AEs were classified according to MedDRA terminology. National drug utilization data were obtained from SUKL to provide an estimate of meloxicam exposure, expressed in defined daily doses (DDD). RESULTS: Over six years, 24 AE reports were identified in the Czech Republic (population 10.7 million). During the same period, meloxicam consumption reached 71,512,140 DDD, corresponding to 4.64 DDD/1000 inhabitants/day. The most frequently reported AEs were hypersensitivity reactions (10 cases), followed by gastrointestinal events (4 cases), nervous system disorders (4 cases), and isolated cardiovascular toxicity (1 case of heart failure). CONCLUSION: In the context of national exposure, only a limited number of meloxicam-related AEs were reported.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NEUROENDOCRINOLOGY LETTERS

ISSN

0172-780X

e-ISSN

2354-4716

Volume of the periodical

46

Issue of the periodical within the volume

3

Country of publishing house

SE - SWEDEN

Number of pages

5

Pages from-to

198-202

UT code for WoS article

001601128900006

EID of the result in the Scopus database

2-s2.0-105021026973