Neonatal mortality risk of large-for-gestational-age and macrosomic live births in 15 countries, including 115.6 million nationwide linked records, 2000-2020

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F25%3AN0000022" target="_blank" >RIV/00023698:_____/25:N0000022 - isvavai.cz</a>

Result on the web

<a href="https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.17706" target="_blank" >https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.17706</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1471-0528.17706" target="_blank" >10.1111/1471-0528.17706</a>

Result language

angličtina

Original language name

Neonatal mortality risk of large-for-gestational-age and macrosomic live births in 15 countries, including 115.6 million nationwide linked records, 2000-2020

Original language description

Objective: We aimed to compare the prevalence and neonatal mortality associated with large for gestational age (LGA) and macrosomia among 115.6 million live births in 15 countries, between 2000 and 2020. Design: Population-based, multi-country study. Setting: National healthcare systems. Population: Liveborn infants. Methods: We used individual-level data identified for the Vulnerable Newborn Measurement Collaboration. We calculated the prevalence and relative risk (RR) of neonatal mortality among live births born at term + LGA (>90th centile, and also >95th and >97th centiles when the data were available) versus term + appropriate for gestational age (AGA, 10th-90th centiles) and macrosomic (>= 4000, >= 4500 and >= 5000 g, regardless of gestational age) versus 2500-3999 g. INTERGROWTH 21st served as the reference population. Main outcome measures: Prevalence and neonatal mortality risks. Results: Large for gestational age was common (median prevalence 18.2%; interquartile range, IQR, 13.5%-22.0%), and overall was associated with a lower neonatal mortality risk compared with AGA (RR 0.83, 95% CI 0.77-0.89). Around one in ten babies were >= 4000 g (median prevalence 9.6% (IQR 6.4%-13.3%), with 1.2% (IQR 0.7%-2.0%) >= 4500 g and with 0.2% (IQR 0.1%-0.2%) >= 5000 g). Overall, macrosomia of >= 4000 g was not associated with increased neonatal mortality risk (RR 0.80, 95% CI 0.69-0.94); however, a higher risk was observed for birthweights of >= 4500 g (RR 1.52, 95% CI 1.10-2.11) and >= 5000 g (RR 4.54, 95% CI 2.58-7.99), compared with birthweights of 2500-3999 g, with the highest risk observed in the first 7 days of life. Conclusions: In this population, birthweight of >= 4500 g was the most useful marker for early mortality risk in big babies and could be used to guide clinical management decisions.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

ISSN

1470-0328

e-ISSN

1471-0528

Volume of the periodical

132

Issue of the periodical within the volume

Suppl. 8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

S109-S120

UT code for WoS article

001110003000001

EID of the result in the Scopus database

2-s2.0-105024020953