Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F15%3A%230005027" target="_blank" >RIV/00023728:_____/15:#0005027 - isvavai.cz</a>
Result on the web
<a href="http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=17&SID=4EaVM2I6BHzE84WbgIk&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=17&SID=4EaVM2I6BHzE84WbgIk&page=1&doc=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/gene.2015.28" target="_blank" >10.1038/gene.2015.28</a>
Alternative languages
Result language
angličtina
Original language name
Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes
Original language description
Genome-wide association study (GWAS) of the major myositis phenotypes, including those with anti-Jo-1 antibodies was conducted in 1710 patients. Single-nucleotide polymorphisms showing strong associations in GWAS were identified in the major histocompatibility complex region for all myositis phenotypes together. Imputation and regression analyses found that alleles comprising the human leukocyte antigen (HLA) 8.1 ancestral haplotype (AH8.1) defined essentially all the genetic risk in the phenotypes studied.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genes and Immunity
ISSN
1466-4879
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
470-480
UT code for WoS article
000363421700005
EID of the result in the Scopus database
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