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Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000024" target="_blank" >RIV/00023728:_____/19:N0000024 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1136/annrheumdis-2019-215046" target="_blank" >http://dx.doi.org/10.1136/annrheumdis-2019-215046</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1136/annrheumdis-2019-215046" target="_blank" >10.1136/annrheumdis-2019-215046</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.

  • Original language description

    We report associations with eight autoantibodies reaching our study-wide significance level of p<2.9x10(-5). Associations with the 8.1 ancestral haplotype were found with anti-Jo-1 (HLA-B*08:01, p=2.28x10(-53) and HLA-DRB1*03:01, p=3.25x10(-9)), anti-PM/Scl (HLA-DQB1*02:01, p=1.47x10(-26)) and anti-cN1A autoantibodies (HLA-DRB1*03:01, p=1.40x10(-11)). Associations independent of this haplotype were found with anti-Mi-2 (HLA-DRB1*07:01, p=4.92x10(-13)) and anti-HMGCR autoantibodies (HLA-DRB1*11, p=5.09x10(-6)). Amino acid positions may be more strongly associated than classical HLA associations; for example with anti-Jo-1 autoantibodies and position 74 of HLA-DRB1 (p=3.47x10(-64)) and position 9 of HLA-B (p=7.03x10(-11)). We report novel genetic associations with HLA-DQB1 anti-TIF1 autoantibodies and identify haplotypes that may differ between adult-onset and juvenile-onset patients with these autoantibodies.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30226 - Rheumatology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    ANNALS OF THE RHEUMATIC DISEASES

  • ISSN

    2464-7209

  • e-ISSN

    1468-2060

  • Volume of the periodical

    78

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    996-1002

  • UT code for WoS article

    000471138100032

  • EID of the result in the Scopus database

    2-s2.0-85067232111