Renal involvement in Systemic Sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000062" target="_blank" >RIV/00023728:_____/19:N0000062 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/19:10406003 RIV/00179906:_____/19:10406003
Result on the web
<a href="https://www.intechopen.com/books/new-insights-into-systemic-sclerosis/renal-involvement-in-systemic-sclerosis" target="_blank" >https://www.intechopen.com/books/new-insights-into-systemic-sclerosis/renal-involvement-in-systemic-sclerosis</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/intechopen.87187" target="_blank" >10.5772/intechopen.87187</a>
Alternative languages
Result language
angličtina
Original language name
Renal involvement in Systemic Sclerosis
Original language description
Scleroderma renal crisis (SRC) is classical renal disease in systemic sclerosis (SSc). SRC is a relatively rare manifestation, approximately in 5% of patients. In terms of severity, manifestation in the form of SRC is the most common cause of acute organ failure. In SSc patients, SRC is defined as a new onset of accelerated arterial hypertension and rapidly progressive anuric or oliguric renal failure. SRC is primarily vascular injury with increased activity of the renin-angiotensin activity. These events lead to release or activation of cytokines and growth factors that result in the typical proliferative vascular lesions. Successful approach is routine use of angiotensin-converting enzyme inhibitors in the treatment of SRC (except prevention) and other advances in renal replacement therapy in SSc management. It is crucial to detect manifestations of SRC early and to manage appropriately in collaboration with intensive care medicine, cardiologists, and nephrologists. In contrast to SRC, clinical presentation of interstitial renal disease is poor, often without evidence of renal abnormality. Interestingly, other renal manifestations are glomerulonephritis and vasculitis. These manifestations are associated with overlapping mechanisms. The objective of this chapter is to focus on actual knowledge about the renal involvement in SSc and current treatment principles and possibilities.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
<a href="/en/project/NV16-33542A" target="_blank" >NV16-33542A: The role of Hsp90 (Heat shock protein 90) in selected rheumatic diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
New Insight into Systemic Sclerosis
ISBN
978-1-83962-204-5
Number of pages of the result
22
Pages from-to
41-62
Number of pages of the book
148
Publisher name
IntechOpen
Place of publication
London
UT code for WoS chapter
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