Idiopathic inflammatory myopathies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F21%3AN0000036" target="_blank" >RIV/00023728:_____/21:N0000036 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10434994
Result on the web
<a href="https://doi.org/10.1038/s41572-021-00321-x" target="_blank" >https://doi.org/10.1038/s41572-021-00321-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41572-021-00321-x" target="_blank" >10.1038/s41572-021-00321-x</a>
Alternative languages
Result language
angličtina
Original language name
Idiopathic inflammatory myopathies
Original language description
Idiopathic inflammatory myopathies (IIM), also known as myositis, are a heterogeneous group of autoimmune disorders with varying clinical manifestations, treatment responses and prognoses. Muscle weakness is usually the classical clinical manifestation but other organs can be affected, including the skin, joints, lungs, heart and gastrointestinal tract, and they can even result in the predominant manifestations, supporting that IIM are systemic inflammatory disorders. Different myositis-specific auto-antibodies have been identified and, on the basis of clinical, histopathological and serological features, IIM can be classified into several subgroups - dermatomyositis (including amyopathic dermatomyositis), antisynthetase syndrome, immune-mediated necrotizing myopathy, inclusion body myositis, polymyositis and overlap myositis. The prognoses, treatment responses and organ manifestations vary among these groups, implicating different pathophysiological mechanisms in each subtype. A deeper understanding of the molecular pathways underlying the pathogenesis and identifying the auto-antigens of the immune reactions in these subgroups is crucial to improving outcomes. New, more homogeneous subgroups defined by auto-antibodies may help define disease mechanisms and will also be important in future clinical trials for the development of targeted therapies and in identifying biomarkers to guide treatment decisions for the individual patient.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NATURE REVIEWS DISEASE PRIMERS
ISSN
2056-676X
e-ISSN
—
Volume of the periodical
7
Issue of the periodical within the volume
Art Nr. 86
Country of publishing house
DE - GERMANY
Number of pages
22
Pages from-to
1-22
UT code for WoS article
000725528900002
EID of the result in the Scopus database
2-s2.0-85120828508