Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F23%3AN0000068" target="_blank" >RIV/00023728:_____/23:N0000068 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/23:10465280 RIV/00216208:11110/23:10465280 RIV/00064165:_____/23:10465280

Result on the web

<a href="https://doi.org/10.1038/s41531-023-00505-0" target="_blank" >https://doi.org/10.1038/s41531-023-00505-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41531-023-00505-0" target="_blank" >10.1038/s41531-023-00505-0</a>

Result language

angličtina

Original language name

Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson's disease

Original language description

Oxidative stress supposedly plays a role in the pathogenesis of Parkinson's disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative stress, was not systematically studied in PD. We aim to compare serum and cerebrospinal fluid (CSF) levels of UA, allantoin, and allantoin/UA ratio in de novo PD patients and controls, and evaluate their associations with clinical severity and the degree of substantia nigra degeneration in PD. We measured serum and CSF levels of UA, allantoin, and allantoin/UA ratio in 86 PD patients (33 females, mean age 57.9 (SD 12.6) years; CSF levels were assessed in 51 patients) and in 40 controls (19 females, 56.7 (14.1) years). PD patients were examined using Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Montreal Cognitive Assessment (MoCA), Scales for Outcomes in Parkinson Disease-Autonomic (SCOPA-AUT), the University of Pennsylvania Smell Identification Test (UPSIT), one-night video-polysomnography, and dopamine transporter single-photon emission computed tomography (DAT-SPECT). Serum allantoin and allantoin/UA ratio were significantly increased in the PD group compared to controls (p < 0.001 and p = 0.002, respectively). Allantoin/UA ratios in serum and CSF were positively associated with the SCOPA-AUT score (p = 0.005 and 0.031, respectively) and RBD presence (p = 0.044 and 0.028, respectively). In conclusion, serum allantoin and allantoin/UA ratio are elevated in patients with de novo PD. Allantoin/UA ratio in serum and CSF is associated with autonomic dysfunction and RBD presence, indicating that higher systemic oxidative stress occurs in PD patients with more diffuse neurodegenerative changes.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NPJ Parkinson's disease

ISSN

2373-8057

e-ISSN

2373-8057

Volume of the periodical

9

Issue of the periodical within the volume

Art. Nr. 60

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

1-7

UT code for WoS article

000968291200001

EID of the result in the Scopus database

2-s2.0-85153118185