CRTAC1: a novel indicator of lung involvement in SSc
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F25%3AN0000022" target="_blank" >RIV/00023728:_____/25:N0000022 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/25:N0000004 RIV/00216208:11110/25:10499905
Result on the web
<a href="https://doi.org/10.1093/rheumatology/keaf269" target="_blank" >https://doi.org/10.1093/rheumatology/keaf269</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/rheumatology/keaf269" target="_blank" >10.1093/rheumatology/keaf269</a>
Alternative languages
Result language
angličtina
Original language name
CRTAC1: a novel indicator of lung involvement in SSc
Original language description
Interstitial lung disease (ILD) is the most frequent cause of mortality in patients with SSc. Cartilage acidic protein-1 (CRTAC1), secreted by alveolar type-2 epithelial cells, is a potential biomarker of lung health. This study explores CRTAC1's role in SSc, focusing on pulmonary involvement. We collected plasma samples from 76 SSc patients (65 females, limited cutaneous (lc)SSc: 45, diffuse cutaneous (dc)SSc: 31, ILD: 43, all fulfilled the 2013 ACR/EULAR criteria) and 89 healthy individuals (HC, 37 females). Patients were examined and assessed for the European Scleroderma Study Group (ESSG) activity score, modified Rodnan skin score (mRSS), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), diffusing capacity for carbon monoxide (DLCO) and Medsger Disease Severity Scale (DSS). CRTAC1 levels were measured using the CRTAC1 IQ-ELISA (Ray Biotech). CRTAC1 levels in plasma were lower in SSc patients compared with HC (P < 0.001). CRTAC1 was decreased in SSc patients with ILD compared with SSc patients without ILD (P = 0.027). Linear modelling showed negative association of CRTAC1 with DSS pulmonary involvement (P = 0.016, β = -2.46) and ESSG activity score (P = 0.047, β = -2.022), and a positive association with DLCO (P = 0.065, β = 1.87), FEV1 (P = 0.1, β = 1.622) and FVC (P = 0.072, β = 1.83). CRTAC1 levels were also decreased in SSc patients with gastrointestinal (P = 0.002) and joint (P = 0.006) involvement and pulmonary arterial hypertension (P = 0.05). Systemic levels of CRTAC1 are decreased in SSc patients, especially among those with ILD, reduced lung function and elevated disease activity. Our findings establish CRTAC1 as a promising biomarker for pulmonary involvement in SSc.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30226 - Rheumatology
Result continuities
Project
<a href="/en/project/LM2023033" target="_blank" >LM2023033: Czech biobank network</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RHEUMATOLOGY
ISSN
1462-0324
e-ISSN
1462-0332
Volume of the periodical
64
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
4834-4838
UT code for WoS article
001503999900001
EID of the result in the Scopus database
2-s2.0-105012932153