Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F09%3A00008238" target="_blank" >RIV/00023736:_____/09:00008238 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation

Original language description

To better define pathogenesis of polycythemia vera (PV), we performed an in vitro erythroid expansion from peripheral blood of controls and PV patients and evaluated the cells for proliferation, apoptosis, erythroid differentiation, and morphology at thedefined time points. PV erythroid progenitors exhibited increased proliferation at days 914 and accelerated maturation at days 714, with a larger S-phase population (40%) than controls (20%) at day 11. Further, we found aberrant expression of p27, cMYBand EPOR in PV erythroid progenitors at the specific stages of erythroid differentiation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NR9236" target="_blank" >NR9236: Endogeneous post-transcriptional regulation of gene function by miRNA</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood Cells, Molecules and Diseases

ISSN

1079-9796

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

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UT code for WoS article

000271076500015

EID of the result in the Scopus database

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