Constant BCR-ABL transcript level less than or equal 0.1% (IS) in patients with CML responding to imatinib with complete cytogenetic remission may indicate mutation analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F10%3A00008261" target="_blank" >RIV/00023736:_____/10:00008261 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Constant BCR-ABL transcript level less than or equal 0.1% (IS) in patients with CML responding to imatinib with complete cytogenetic remission may indicate mutation analysis
Original language description
This work is dealing with the important question of when should be CML patients screened for BCR-ABL kinase domain mutation. We showed that the expression of BCR-ABL plateau in a minimum of 3 subsequent samples from regular BCR-ABL transcript level monitoring may be a reliable indicator for mutation testing. The BCR-ABL constant levels ?0.1% clearly selected patients in complete cytogenetic remission who did not achieve major molecular response for mutation analysis. This approach reduces the number ofexaminations for mutation analysis and is a cost-effective alternative applicable in clinical practice.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR8758" target="_blank" >NR8758: Early markers of resistance to imatinib in chronic myeloid leukemia treatment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Hematology
ISSN
0301-472X
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000273142300004
EID of the result in the Scopus database
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