Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F11%3A00009155" target="_blank" >RIV/00023736:_____/11:00009155 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2011_01_35" target="_blank" >http://dx.doi.org/10.4149/neo_2011_01_35</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2011_01_35" target="_blank" >10.4149/neo_2011_01_35</a>

Result language

angličtina

Original language name

Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence

Original language description

Histone deacetylase inhibitors (HDACi) are emerging new class of anticancer agents that act by inhibiting cell growth, inducing cell cycle arrest and apoptosis of various cancer cells. However, in some conditions, apoptosis can be blocked and non apoptotic cell death and irreversible growth arrest, namely senescence, can be activated as potential tumor-suppressor mechanism. Here we evaluated the dosage effects of HDAC inhibitors suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) in a seriesof human leukaemia cell lines.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

10

Pages from-to

35-44

UT code for WoS article

000290695500006

EID of the result in the Scopus database

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