Expression of soluble TGF-beta receptor II by recombinant Vaccinia virus enhances E7 specific immunotherapy of HPV16 tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F11%3A00009280" target="_blank" >RIV/00023736:_____/11:00009280 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2011_03_181" target="_blank" >http://dx.doi.org/10.4149/neo_2011_03_181</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2011_03_181" target="_blank" >10.4149/neo_2011_03_181</a>
Alternative languages
Result language
angličtina
Original language name
Expression of soluble TGF-beta receptor II by recombinant Vaccinia virus enhances E7 specific immunotherapy of HPV16 tumors
Original language description
Therapeutic immunization with double recombinants of vaccinia virus (VACV) co-expressing sT?RII increased rejection of established TC-1 tumors in C57BL/6 mice in comparison with single recombinant expressing SigE7LAMP. Recombinant VACV derived from vaccination strain Praha expressed either the sT?RII (ectodomain) or chimeric protein fused to immunoglobulin Fc fragment (sT?RII-Fc-Jun) under control of two different promotors together with the immunogenic tumor associated antigen HPV16 E7 oncoprotein in aform of SigE7LAMP fusion molecule. The ability of soluble receptors to bind TGF-? in vitro was proved. Immunization of mice with double recombinant viruses and virus expressing SigE7LAMP only led to eliciting similar response of E7 specific CD8+ T cellsas detected by IFN-? ELISPOT.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10660" target="_blank" >NS10660: Development of experimental vaccine against WT 1 for immunotherapy of tumors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
3
Country of publishing house
SK - SLOVAKIA
Number of pages
8
Pages from-to
181-188
UT code for WoS article
000290695800001
EID of the result in the Scopus database
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