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Expression of soluble TGF-beta receptor II by recombinant Vaccinia virus enhances E7 specific immunotherapy of HPV16 tumors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F11%3A00009280" target="_blank" >RIV/00023736:_____/11:00009280 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.4149/neo_2011_03_181" target="_blank" >http://dx.doi.org/10.4149/neo_2011_03_181</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4149/neo_2011_03_181" target="_blank" >10.4149/neo_2011_03_181</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression of soluble TGF-beta receptor II by recombinant Vaccinia virus enhances E7 specific immunotherapy of HPV16 tumors

  • Original language description

    Therapeutic immunization with double recombinants of vaccinia virus (VACV) co-expressing sT?RII increased rejection of established TC-1 tumors in C57BL/6 mice in comparison with single recombinant expressing SigE7LAMP. Recombinant VACV derived from vaccination strain Praha expressed either the sT?RII (ectodomain) or chimeric protein fused to immunoglobulin Fc fragment (sT?RII-Fc-Jun) under control of two different promotors together with the immunogenic tumor associated antigen HPV16 E7 oncoprotein in aform of SigE7LAMP fusion molecule. The ability of soluble receptors to bind TGF-? in vitro was proved. Immunization of mice with double recombinant viruses and virus expressing SigE7LAMP only led to eliciting similar response of E7 specific CD8+ T cellsas detected by IFN-? ELISPOT.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS10660" target="_blank" >NS10660: Development of experimental vaccine against WT 1 for immunotherapy of tumors</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neoplasma

  • ISSN

    0028-2685

  • e-ISSN

  • Volume of the periodical

    58

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    8

  • Pages from-to

    181-188

  • UT code for WoS article

    000290695800001

  • EID of the result in the Scopus database