Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F12%3A00009600" target="_blank" >RIV/00023736:_____/12:00009600 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2012_022" target="_blank" >http://dx.doi.org/10.4149/neo_2012_022</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2012_022" target="_blank" >10.4149/neo_2012_022</a>

Result language

angličtina

Original language name

Monitoring of methylation changes in 9p21 region in patients with myelodysplastic syndromes and acute myeloid leukemia

Original language description

Epigenetic de novo methylation of CpG islands is an important event in malignant transformation. Two genes are frequently methylated: cyclin-dependent kinase inhibitor 2B (CDKN2B) and cyclin-dependent kinase inhibitor 2A (CDKN2A). In our study methylation of these genes was studied in 63 patients with myelodysplastic syndromes (MDS), 2 with myelodysplastic/myeloproliferative neoplasms (MDS/MPN) and 13 with acute myeloid leukemia (AML). Five patients were monitored during 5-azacytidine treatment. Twenty-six healthy donors were tested in a control group.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

7

Pages from-to

168-174

UT code for WoS article

000301083700007

EID of the result in the Scopus database

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