Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F12%3A00009959" target="_blank" >RIV/00023736:_____/12:00009959 - isvavai.cz</a>
Result on the web
<a href="http://journals.lww.com/immunotherapy-journal/Abstract/2012/07000/Immunization_With_WT1_derived_Peptides_by.4.aspx" target="_blank" >http://journals.lww.com/immunotherapy-journal/Abstract/2012/07000/Immunization_With_WT1_derived_Peptides_by.4.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/CJI.0b013e3182618381" target="_blank" >10.1097/CJI.0b013e3182618381</a>

Result language
angličtina
Original language name
Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice
Original language description
The expression of the transcription factor encoded by the Wilms tumor gene 1 (WT1) is associated with a variety of human cancers. WT1 protein has been reported to serve as a target antigen for tumor-specific immune responses. We observed that the immunization of mice with peptide vaccines derived from WT1 in a mixture with the CpG adjuvant (ODN 1826) by tattoo administration was superior to subcutaneous delivery of the peptides in combination with CpG formulated with the mineral oil adjuvant or a DNA vaccine or a recombinant vaccinia virus vaccine expressing the truncated WT1 protein. Tattooing with the WT1122?140 and WT1126?134 peptide elicited the response of WT1-specific interferon-??producing T cells. Peptide vaccine administered with a tattoo device had an antitumor effect on the growth of the prostate tumor cell line TRAMP-C2, provided that the transforming growth factor-beta produced by tumor cells was neutralized by anti-TGFbeta monoclonal antibody.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NS10660" target="_blank" >NS10660: Development of experimental vaccine against WT 1 for immunotherapy of tumors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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