Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F13%3A00010739" target="_blank" >RIV/00023736:_____/13:00010739 - isvavai.cz</a>

Result on the web

<a href="http://www.jhoonline.org/content/pdf/1756-8722-6-58.pdf" target="_blank" >http://www.jhoonline.org/content/pdf/1756-8722-6-58.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1756-8722-6-58" target="_blank" >10.1186/1756-8722-6-58</a>

Result language

angličtina

Original language name

Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome

Original language description

Myelodysplastic syndromes (MDS) are hematological malignancies of unclear etiology where oxidative stress may contribute to the pathogenesis. Methylarginines, naturally occurring inhibitors of NO synthase, can increase superoxide generation from uncoupled NO synthase. We found significant increase in concentrations of asymmetric dimethylarginine (0.84 0.32 ?mol/L, p = 0.0022) and malondialdehyde (0.77 0.11 ?mol/L, p < 0.001) in sera of MDS patients vs controls (asymmetric dimethylarginine: 0.56 0.16 ?mol/L, malondialdehyde: 0.52 0.07 ?mol/L). On the contrary, nitrites concentrations were significantly decreased in MDS patients (1.71 0.46 ?mol/L, p = 0.0028) vs controls (2.16 0.38 ?mol/L). We suppose that the oxidative stress in MDS is enhanced due to methylated arginines influence on NO synthase activity impairment.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of hematology & oncology

ISSN

1756-8722

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

2

Pages from-to

"art. no. 58"

UT code for WoS article

000323675900001

EID of the result in the Scopus database

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