Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F15%3A00011196" target="_blank" >RIV/00023736:_____/15:00011196 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/15:10294608 RIV/00216208:11110/15:10294608 RIV/00216208:11130/15:10294608 RIV/00064203:_____/15:10294608
Result on the web
<a href="http://www.scopus.com/inward/record.url?eid=2-s2.0-84938717670&partnerID=40&md5=8be21d8bdeb67e8782e9b3348524a02a" target="_blank" >http://www.scopus.com/inward/record.url?eid=2-s2.0-84938717670&partnerID=40&md5=8be21d8bdeb67e8782e9b3348524a02a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4161/21624011.2014.965570" target="_blank" >10.4161/21624011.2014.965570</a>
Alternative languages
Result language
angličtina
Original language name
Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma
Original language description
In this study, we analyzed a detailed immune profile of tumor samples from HNSCC patients with respect to their HPV status. We analyzed the characteristics of immune cell infiltrates, including the frequency and distribution of antigen-presenting cells and naïve, regulatory and effector T cells and the cytokine and chemokine levels in tumor tissue. The presence of a high level of intratumoral immune cell infiltrates might play a crucial role in the significantly better response of HPV-positive patients to standard therapy and their favorable clinical outcome. Characterization of the HNSCC immune profile might be a valuable prognostic tool in addition to HPV status and might help identify novel targets for therapeutic strategies, including cancer immunotherapy
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
OncoImmunology
ISSN
2162-4011
e-ISSN
—
Volume of the periodical
4
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"art. no. e965570"
UT code for WoS article
000349387800004
EID of the result in the Scopus database
2-s2.0-84938717670