Time-dependent changes in mortality and transformation risk in MDS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F16%3A00011565" target="_blank" >RIV/00023736:_____/16:00011565 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1182/blood-2016-02-700054" target="_blank" >http://dx.doi.org/10.1182/blood-2016-02-700054</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1182/blood-2016-02-700054" target="_blank" >10.1182/blood-2016-02-700054</a>

Result language
angličtina
Original language name
Time-dependent changes in mortality and transformation risk in MDS
Original language description
n myelodysplastic syndromes (MDSs), the evolution of risk for disease progression or death has not been systematically investigated despite being crucial for correct interpretation of prognostic risk scores. In a multicenter retrospective study, we described changes in risk over time, the consequences for basal prognostic scores, and their potential clinical implications. Our data regarding time-dependent performance of prognostic scores reflect the disparate change of risks in MDS subpopulations. Lower-risk patients at diagnosis remain lower risk whereas initially high-risk patients demonstrate decreasing risk over time. This change of risk should be considered in clinical decision making.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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