Posttranslational modifications of red blood cell ghost proteins as ´signatures´ for distinguishing between low- and high-risk myelodysplastic syndrome patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F17%3A00011625" target="_blank" >RIV/00023736:_____/17:00011625 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4274/tjh.2016.0251" target="_blank" >http://dx.doi.org/10.4274/tjh.2016.0251</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4274/tjh.2016.0251" target="_blank" >10.4274/tjh.2016.0251</a>
Alternative languages
Result language
angličtina
Original language name
Posttranslational modifications of red blood cell ghost proteins as ´signatures´ for distinguishing between low- and high-risk myelodysplastic syndrome patients
Original language description
Myelodysplastic syndrome (MDS) comprises a heterogenic group of oncohematological diseases that affect hematopoiesis. Although the precise cause of MDS is unknown, multiple factors are involved, one of the most widely implicated of which is oxidative stress. However, it is unclear whether oxidative stress is a cause of MDS or an effect of other pathological mechanisms. Red blood cells (RBC) are the first cells exposed to stress stimuli. They are highly vulnerable to free radical accumulation, which leads to the oxidative stress that induces damage in proteins and other biomacromolecules. In MDS, the RBC proteome can be affected by effects of the peripheral blood environment of and/or by abnormal processes possibly caused by oxidative stress during hematopoiesis in bone marrow. Therefore, we chose red cell membranes (ghosts) as a model biological material.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiophotonics for future health care</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Turkish Journal of Haematology
ISSN
1300-7777
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
1
Country of publishing house
TR - TURKEY
Number of pages
3
Pages from-to
111-113
UT code for WoS article
000398059500024
EID of the result in the Scopus database
2-s2.0-85014469972