Therapeutic potential of hepcidin: the master regulator of iron metabolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F17%3A00011640" target="_blank" >RIV/00023736:_____/17:00011640 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10361854

Result on the web

<a href="http://dx.doi.org/10.1016/j.phrs.2016.11.010" target="_blank" >http://dx.doi.org/10.1016/j.phrs.2016.11.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.phrs.2016.11.010" target="_blank" >10.1016/j.phrs.2016.11.010</a>

Result language

angličtina

Original language name

Therapeutic potential of hepcidin: the master regulator of iron metabolism

Original language description

Iron is an essential biogenic element for both prokaryotic and eukaryotic cells. In humans iron is present in hundreds of different metalloproteins. The peptide hormone hepcidin serves as a master regulator of iron homeostasis on the level of single cells and whole organism - by altering cell surface expression of cellular iron exporter - protein ferroportin. Altered levels of extracellular hepcidin lead to pathological conditions such as hemochromatosis and iron loading or, on the other side, iron restrictive anemias. Therapeutic modulation of hepcidin is a new and promising approach to treatment of these conditions. In this review, a summary of the current knowledge of hepcidin function, regulation and pathological involvements are provided, followed by a section covering the therapeutic potential of hepcidin and the current strategies how to modulate its levels and biological functions for therapeutic purposes

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacological research

ISSN

1043-6618

e-ISSN

—

Volume of the periodical

115

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

242-254

UT code for WoS article

000392790400023

EID of the result in the Scopus database

2-s2.0-85002878181