Baseline characteristics predicting very good outcome of allogeneic hematopoietic cell transplantation in young patients with high cytogenetic risk chronic lymphocytic leukemia: a retrospective analysis from the chronic malignancies working party of the EBMT
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F17%3A00011777" target="_blank" >RIV/00023736:_____/17:00011777 - isvavai.cz</a>
Alternative codes found
RIV/00669806:_____/17:10366038
Result on the web
<a href="http://dx.doi.org/10.1016/j.clml.2017.06.007" target="_blank" >http://dx.doi.org/10.1016/j.clml.2017.06.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clml.2017.06.007" target="_blank" >10.1016/j.clml.2017.06.007</a>
Alternative languages
Result language
angličtina
Original language name
Baseline characteristics predicting very good outcome of allogeneic hematopoietic cell transplantation in young patients with high cytogenetic risk chronic lymphocytic leukemia: a retrospective analysis from the chronic malignancies working party of the EBMT
Original language description
Patients with genetically high-risk relapsed/refractory chronic lymphocytic leukemia have shorter median progression-free survival (PFS) with kinase- and BCL2-inhibitors (KI, BCL2i). Allogeneic hematopoietic stem cell transplantation (alloHCT) may result in sustained PFS, especially in younger patients because of its age-dependent non-relapse mortality (NRM) risk, but outcome data are lacking for this population. Low predicted NRM and high 8-year PFS in favorable transplant high cytogenetic risk patients compares favorably with outcomes with KI or BCL2i. Taking into account the amount of uncertainty for predicting survival after alloHCT and after sequential administration of KI and BCL2i, alloHCT remains a valid option for younger patients with high cytogenetic risk chronic lymphocytic leukemia with a well-HLA-matched donor.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical lymphoma, myeloma & leukemia
ISSN
2152-2650
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
"667"-"675.e2"
UT code for WoS article
000415142700008
EID of the result in the Scopus database
2-s2.0-85021744361