WT1 gene expression in peripheral blood before and after allogeneic stem cell transplantation is a clinically relevant prognostic marker in AML: a single-center 14-year experience

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00013158" target="_blank" >RIV/00023736:_____/21:00013158 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10427885

Result on the web

<a href="https://doi.org/10.1016/j.clml.2020.09.008" target="_blank" >https://doi.org/10.1016/j.clml.2020.09.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clml.2020.09.008" target="_blank" >10.1016/j.clml.2020.09.008</a>

Result language

angličtina

Original language name

WT1 gene expression in peripheral blood before and after allogeneic stem cell transplantation is a clinically relevant prognostic marker in AML: a single-center 14-year experience

Original language description

Recent years have shown that minimal or measurable residual disease (MRD) is one of the most important independent prognostic factors in acute myeloid leukemia (AML), and its monitoring is crucial in treatment planning and risk stratification. The basis of such stratification is the identification and monitoring of a specific MRD marker in individual patients. Wilms’ tumor gene 1 (WT1) encodes a transcription factor that is overexpressed in several hematologic malignancies, including AML in up to 80% to 90% of cases. Thus, it is not a marker specific for AML, but rather reflects abnormal myelopoiesis. In this work, we summarized our experience with WT1 monitoring before allo-HSCT, but also the usefulness of this marker in long-term follow-up after allo-HSCT.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical lymphoma myeloma & leukemia

ISSN

2152-2650

e-ISSN

—

Volume of the periodical

21

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

"e145"-"e151"

UT code for WoS article

000621041700006

EID of the result in the Scopus database

2-s2.0-85095797057