Sensitivity and reliability of DNA-based mutation analysis by allele-specific digital PCR to follow resistant BCR-ABL1-positive cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00013225" target="_blank" >RIV/00023736:_____/21:00013225 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/21:10427921
Result on the web
<a href="https://doi.org/10.1038/s41375-021-01226-0" target="_blank" >https://doi.org/10.1038/s41375-021-01226-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-021-01226-0" target="_blank" >10.1038/s41375-021-01226-0</a>

Result language
angličtina
Original language name
Sensitivity and reliability of DNA-based mutation analysis by allele-specific digital PCR to follow resistant BCR-ABL1-positive cells
Original language description
Mutations in the kinase domain (KD) of BCR-ABL1 are known causes of resistance to tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) and Ph-positive acute lymphoblastic leukemia (Ph+ ALL), and detection is routinely performed at the transcript level.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology

Project
<a href="/en/project/GA18-18407S" target="_blank" >GA18-18407S: Epigenetic, genetic and molecular factors required for mutagenesis of oncogene BCR-ABL1 during Ph+ cells treatment with tyrosine kinase inhibitor</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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