Fibrin clot formation under oxidative stress conditions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00013249" target="_blank" >RIV/00023736:_____/21:00013249 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/21:00001054 RIV/00216208:11110/21:10429390
Result on the web
<a href="https://doi.org/10.3390/antiox10060923" target="_blank" >https://doi.org/10.3390/antiox10060923</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/antiox10060923" target="_blank" >10.3390/antiox10060923</a>
Alternative languages
Result language
angličtina
Original language name
Fibrin clot formation under oxidative stress conditions
Original language description
The aim was to examine the effects of oxidative stress conditions on fibrin clot formation in arterial atherothrombotic disorders. We studied the changes in in vitro fibrin network formation in three groups of patients—with acute coronary syndrome (ACS), with significant carotid artery stenosis (SCAS), and with acute ischemic stroke (AIS), as well as a control group. The level of oxidative stress marker malondialdehyde measured by LC-MS/MS was higher in SCAS and AIS patients compared with controls. Turbidic methods revealed a higher final optical density and a prolonged lysis time in the clots of these patients. Electron microscopy was used to visualize changes in the in vitro-formed fibrin network. Fibers from patients with AIS were significantly thicker in comparison with control and ACS fibers. The number of fibrin fibers in patients with AIS was significantly lower in comparison with ACS and control groups. Thus, oxidative stress-medi-ated changes in fibrin clot formation, structure and dissolution may affect the effectiveness of thrombolytic therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV18-08-00149" target="_blank" >NV18-08-00149: Critical evaluation of the lipidome in acute coronary syndrome and acute stroke patients in correlation with the level of oxidative stress</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antioxidants
ISSN
2076-3921
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
6
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
"art. no. 923"
UT code for WoS article
000665570200001
EID of the result in the Scopus database
2-s2.0-85107281202