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Enzymatically produced piggyBac transposon vectors for efficient non-viral manufacturing of CD19-specific CAR T cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F21%3A00013342" target="_blank" >RIV/00023736:_____/21:00013342 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/21:10437092

  • Result on the web

    <a href="https://doi.org/10.1016/j.omtm.2021.08.006" target="_blank" >https://doi.org/10.1016/j.omtm.2021.08.006</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.omtm.2021.08.006" target="_blank" >10.1016/j.omtm.2021.08.006</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Enzymatically produced piggyBac transposon vectors for efficient non-viral manufacturing of CD19-specific CAR T cells

  • Original language description

    The piggyBac transposon system provides a non-viral alternative for cost-efficient and simple chimeric antigen receptor (CAR) T cell production. The generation of clinical-grade CAR T cells requires strict adherence to current good manufacturing practice (cGMP) standards. Unfortunately, the high costs of commonly used lentiviral or retroviral vectors limit the manufacturing of clinical-grade CAR T cells in many non-commercial academic institutions. Here, we present a manufacturing platform for highly efficient generation of CD19-specific CAR T cells (CAR19 T cells) based on co-electroporation of linear DNA transposon and mRNA encoding the piggyBac transposase.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

    <a href="/en/project/NV19-08-00147" target="_blank" >NV19-08-00147: Pre-clinical validation of cGMP production of CAR T-cells for solid tumorstherapy</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular therapy-methods & clinical development

  • ISSN

    2329-0501

  • e-ISSN

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    [December]

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    119-127

  • UT code for WoS article

    000748748500011

  • EID of the result in the Scopus database

    2-s2.0-85122703770