PAK1 and PAK2 in cell metabolism regulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F22%3A00013287" target="_blank" >RIV/00023736:_____/22:00013287 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/jcb.30175" target="_blank" >https://doi.org/10.1002/jcb.30175</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jcb.30175" target="_blank" >10.1002/jcb.30175</a>
Alternative languages
Result language
angličtina
Original language name
PAK1 and PAK2 in cell metabolism regulation
Original language description
We analyzed the impact of PAK inhibition by small molecule inhibitors, small interfering RNA, or gene knockout on the rates of mitochondrial respiration and aerobic glycolysis. Pharmacological inhibition of PAK group I by IPA-3 induced a strong decrease in metabolic rates in human adherent cancer cell lines, leukemia/lymphoma cell lines, and primary leukemia cells. The immediate effect of FRAX597, which inhibits PAK kinase activity, was moderate, indicating that PAK nonkinase functions are essential for cell metabolism.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of cellular biochemistry
ISSN
0730-2312
e-ISSN
—
Volume of the periodical
123
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
375-389
UT code for WoS article
000715637300001
EID of the result in the Scopus database
2-s2.0-85118580247