Non-mutated nucleophosmin 1 is recognized by the CD8+ T lymphocytes of an AML patient after the transplantation of hematopoietic stem cells from an HLA-haploidentical donor
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F22%3A00013395" target="_blank" >RIV/00023736:_____/22:00013395 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10445078
Result on the web
<a href="https://doi.org/10.3390/curroncol29050239" target="_blank" >https://doi.org/10.3390/curroncol29050239</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/curroncol29050239" target="_blank" >10.3390/curroncol29050239</a>
Alternative languages
Result language
angličtina
Original language name
Non-mutated nucleophosmin 1 is recognized by the CD8+ T lymphocytes of an AML patient after the transplantation of hematopoietic stem cells from an HLA-haploidentical donor
Original language description
Our study describes an AML patient whose leukemia cells carried the NPM1c+ mutation, and who was the recipient of allogeneic HSCT from a haploidentical donor. The patient raised a robust allorestricted CD8+ T cell response directed against the NPM1wt protein. Favourably, the response against NPM1wt was not accompanied by side effects such as GvHD. Moreover, the induction of a high NPM1wt specific response coincided with the decrease in NPM1c+ transcripts detected, implying a beneficial graft versus leukemia effect. On the basis of these results, we suppose that TCRs from allorestricted NPM1wt-specific T cells are worth studying in other recipients of grafts from haploidentical donors as a possible tool for TCR gene therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current oncology
ISSN
1198-0052
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
2928-2934
UT code for WoS article
000804920800001
EID of the result in the Scopus database
2-s2.0-85129360101