Proteolysis-targeting chimeras (PROTACs) as novel biotechnology for cancer therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F22%3A00013431" target="_blank" >RIV/00023736:_____/22:00013431 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/B978-0-323-90042-3.15001-7" target="_blank" >https://doi.org/10.1016/B978-0-323-90042-3.15001-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-323-90042-3.15001-7" target="_blank" >10.1016/B978-0-323-90042-3.15001-7</a>

Result language
angličtina
Original language name
Proteolysis-targeting chimeras (PROTACs) as novel biotechnology for cancer therapy
Original language description
The ubiquitin-proteasome system (UPS) is an important pathway in cells that mediates the metabolic recycling of proteins and their disposal. A ubiquitin is attached to the e-amino group of a lysine amino acid residue on the amino-terminus in a substrate protein and starts polyubiquitination of this protein. This process involves three enzymes (E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, and E3 ubiquitin ligase). The C-terminus of each ubiquitin is linked to a specific lysine residue (Lys48) of the previous ubiquitin if the substrate protein is destined for degradation in proteasome.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Biotechnology in healthcare, volume 2: applications and initiatives
ISBN
9780323900423
Number of pages of the result
18
Pages from-to
71-88
Number of pages of the book
300
Publisher name
Elsevier: Academic Press
Place of publication
Cambridge, Massachusetts
UT code for WoS chapter
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