Should anti-thymocyte globulin be added in post-transplant cyclophosphamide based matched unrelated donor peripheral blood stem cell transplantation for acute myeloid leukemia?: a study on behalf of the Acute Leukemia Working Party of the EBMT
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F22%3A00013442" target="_blank" >RIV/00023736:_____/22:00013442 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41409-022-01816-1" target="_blank" >https://doi.org/10.1038/s41409-022-01816-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41409-022-01816-1" target="_blank" >10.1038/s41409-022-01816-1</a>
Alternative languages
Result language
angličtina
Original language name
Should anti-thymocyte globulin be added in post-transplant cyclophosphamide based matched unrelated donor peripheral blood stem cell transplantation for acute myeloid leukemia?: a study on behalf of the Acute Leukemia Working Party of the EBMT
Original language description
In this registry-based study which includes acute myeloid leukemia patients who underwent a matched unrelated donor allogeneic peripheral-blood stem cell transplantation in complete remission and received post-transplant cyclophosphamide (PTCY) as graft-versus-host disease (GvHD) prophylaxis, we compared 421 recipients without anti-thymocyte globulin (ATG) with 151 patients with ATG. The Cox-model showed no difference between PTCY + ATG and PTCY alone with respect to acute and chronic GvHD of all grades, non-relapse mortality, relapse, leukemia-free survival, overall survival, and GvHD-free-relapse-free survival between study cohorts. Our results highlight that the addition of ATG in PTCY does not provide any extra benefit in terms of further GvHD reduction, better GRFS or better survival.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bone marrow transplantation
ISSN
0268-3369
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1774-1780
UT code for WoS article
000851058200001
EID of the result in the Scopus database
2-s2.0-85137561761