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The homozygous type II antithrombin deficient pregnant woman monitored by thrombin generation assay

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F23%3A00013580" target="_blank" >RIV/00023736:_____/23:00013580 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/23:10469882 RIV/00064165:_____/23:10469882

  • Result on the web

    <a href="http://dx.doi.org/10.7754/Clin.Lab.2023.230435" target="_blank" >http://dx.doi.org/10.7754/Clin.Lab.2023.230435</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.7754/Clin.Lab.2023.230435" target="_blank" >10.7754/Clin.Lab.2023.230435</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The homozygous type II antithrombin deficient pregnant woman monitored by thrombin generation assay

  • Original language description

    We present the case study of a 28-year-old pregnant woman with antithrombin deficiency who was treated with low-molecular-weight heparin (LMWH). Due to severe homozygous type II antithrombin heparin binding site (HBS) deficiency, the thrombin generation (TG) was monitored in this woman via the Thrombin Generation Assay (TGA). We used Siemens diagnostic kits Berichrom® Antithrombin III (IIa) and INNOVANCE® Antithrombin (Xa) to determine antithrombin activity. We used a chromogenic method for determination of factor Xa (FXa) inhibition. There were no thrombotic complications during the whole pregnancy of the observed woman. Antithrombin was administered before and after delivery, which was significantly reflected in the decrease in thrombin generation. Conclusions: Consistent monitoring of thrombin generation with LMWH anticoagulant therapy administration during pregnancy together with antithrombin administration before and after delivery can improve the overall condition of pregnant women and the quality of their care.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical laboratory

  • ISSN

    1433-6510

  • e-ISSN

  • Volume of the periodical

    69

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    5

  • Pages from-to

    2171-2175

  • UT code for WoS article

    001109223200018

  • EID of the result in the Scopus database

    2-s2.0-85175585530