ABC transporters are predictors of treatment failure in acute myeloid leukaemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013588" target="_blank" >RIV/00023736:_____/24:00013588 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10472810 RIV/00216208:11310/24:10472810
Result on the web
<a href="https://doi.org/10.1016/j.biopha.2023.115930" target="_blank" >https://doi.org/10.1016/j.biopha.2023.115930</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biopha.2023.115930" target="_blank" >10.1016/j.biopha.2023.115930</a>

Result language
angličtina
Original language name
ABC transporters are predictors of treatment failure in acute myeloid leukaemia
Original language description
To date, no chemoresistance predictors are included in acute myeloid leukaemia (AML) prognostic scoring systems to distinguish responding and refractory AML patients prior to chemotherapy. ABC transporters have been described as altering AML chemosensitivity. However, a relevant study investigating their role at various molecular levels was lacking. ABC transporters, especially ABCC1 seem to contribute substantially to AML chemoresistance. A detailed understanding of chemoresistance mechanisms and the clinical implications of chemosensitivity predictors may lead to alternative therapeutic approaches for AML patients with unveiled chemoresistance signatures.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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