Unstable major molecular response as a trigger for next generation sequencing-based BCR::ABL1 mutation testing in chronic myeloid leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013632" target="_blank" >RIV/00023736:_____/24:00013632 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/ajh.27232" target="_blank" >https://doi.org/10.1002/ajh.27232</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.27232" target="_blank" >10.1002/ajh.27232</a>

Result language
angličtina
Original language name
Unstable major molecular response as a trigger for next generation sequencing-based BCR::ABL1 mutation testing in chronic myeloid leukemia
Original language description
In chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs), molecular response (MR) milestones have been identified that harbor prognostic significance. Major molecular response (MMR)—defined as 3-log reduction in BCR::ABL1 transcript levels from the standardized baseline on the International Scale (IS)—was the very first of such MR milestones to be recognized: It emerged at the time of the IRIS trial as a “safe haven” protecting from loss of response and progression.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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