A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013647" target="_blank" >RIV/00023736:_____/24:00013647 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/24:00081599 RIV/00216224:14110/24:00136824
Result on the web
<a href="https://doi.org/10.1038/s41598-024-57400-8" target="_blank" >https://doi.org/10.1038/s41598-024-57400-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-024-57400-8" target="_blank" >10.1038/s41598-024-57400-8</a>
Alternative languages
Result language
angličtina
Original language name
A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis
Original language description
Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While the significance of the gut microbiome on multiple sclerosis pathogenesis is established, the underlining mechanisms are unknown. We found that serum levels of the microbial postbiotic tryptophan metabolite indole-3-carboxaldehyde (3-IAld) inversely correlated with disease duration in multiple sclerosis patients. Much like the host-derived tryptophan derivative L-Kynurenine, 3-IAld would bind and activate the Aryl hydrocarbon Receptor (AhR), which, in turn, controls endogenous tryptophan catabolic pathways. As a result, in peripheral lymph nodes, microbial 3-IAld, affected mast-cell tryptophan metabolism, forcing mast cells to produce serotonin via Tph1. We thus propose a protective role for AhR-mast-cell activation driven by the microbiome, whereby natural metabolites or postbiotics will have a physiological role in immune homeostasis and may act as therapeutic targets in autoimmune diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
"art. no. 6651"
UT code for WoS article
001192455600032
EID of the result in the Scopus database
2-s2.0-85188108700