Clonal hematopoiesis as a predictor of subsequent myeloid cancers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013693" target="_blank" >RIV/00023736:_____/24:00013693 - isvavai.cz</a>
Result on the web
<a href="https://novapublishers.com/shop/advances-in-genetics-research-volume-22/" target="_blank" >https://novapublishers.com/shop/advances-in-genetics-research-volume-22/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Clonal hematopoiesis as a predictor of subsequent myeloid cancers
Original language description
Myeloid neoplasms including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) originate from hematopoietic stem cells through the process known as clonal hematopoiesis. This process is characterized by the sequential acquisition of genetic and epigenetic alterations associated with impaired differentiation and increased proliferation. Myeloid neoplasms frequently develop from premalignant precursors that are detectable in many healthy individuals. These precursor states, such as clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS), could allow earlier diagnosis of MDS. Clonal hematopoiesis in healthy persons and patients undergoing chemotherapy for non-hematologic cancer, and in autologous and allogeneic stem cell transplantation could be identified.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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