JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F24%3A00013716" target="_blank" >RIV/00023736:_____/24:00013716 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s43440-024-00649-7" target="_blank" >https://doi.org/10.1007/s43440-024-00649-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s43440-024-00649-7" target="_blank" >10.1007/s43440-024-00649-7</a>

Result language
angličtina
Original language name
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells
Original language description
The mechanistic target of rapamycin (mTOR) is a crucial regulator of cell metabolic activity. It forms part of several distinct protein complexes, particularly mTORC1 and mTORC2. The lack of specific inhibitors still hampers the attribution of mTOR functions to these complexes. JR-AB2-011 has been reported as a specific mTORC2 inhibitor preventing mTOR binding to RICTOR, a unique component of mTORC2. We aimed to describe the effects of JR-AB2-011 in leukemia/lymphoma cells, where the mTOR pathway is often aberrantly activated.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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