Single or double induction with 7 + 3 containing standard or high-dose daunorubicin for newly diagnosed AML: the randomized daunodouble trial by the study Alliance Leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F25%3A00013722" target="_blank" >RIV/00023736:_____/25:00013722 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43927555 RIV/65269705:_____/25:00081020 RIV/00064173:_____/25:43927555
Result on the web
<a href="https://doi.org/10.1200/JCO.24.00235" target="_blank" >https://doi.org/10.1200/JCO.24.00235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1200/JCO.24.00235" target="_blank" >10.1200/JCO.24.00235</a>
Alternative languages
Result language
angličtina
Original language name
Single or double induction with 7 + 3 containing standard or high-dose daunorubicin for newly diagnosed AML: the randomized daunodouble trial by the study Alliance Leukemia
Original language description
To determine the optimal daunorubicin dose and number of 7 + 3 induction cycles in newly diagnosed AML, this randomized controlled trial compared a once daily dose of 60 mg/m2 with 90 mg/m2 daunorubicin in the first 7 + 3 induction and one versus two cycles of 7 + 3 induction. The use of 90 mg/m2 daunorubicin once daily in the context of classical 7 + 3 induction does not significantly improve early response and does not lead to higher remission rates or longer survival than 60 mg/m2 once daily. In patients with a good early response after first induction, a second induction has only a limited impact on RFS and does not result in an OS benefit.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of clinical oncology
ISSN
0732-183X
e-ISSN
—
Volume of the periodical
43
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
65-74
UT code for WoS article
001091456900051
EID of the result in the Scopus database
2-s2.0-85204701862