Age- and sex-dependent effects of ethanol on hippocampal hemicholinium-3 sensitive choline carriers during postnatal development of rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F03%3A00000305" target="_blank" >RIV/00023752:_____/03:00000305 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Age- and sex-dependent effects of ethanol on hippocampal hemicholinium-3 sensitive choline carriers during postnatal development of rats

Original language description

Vulnerability of hippocampal hemicholinium-3 (HC-3) sensitive carriers to ethanol was evaluated in vitro during rat postnatal development. The high-affinity uptake of (3H)choline (HACU) and the specific binding of (3H)HC-3 were measured on synaptosomes from 7-, 14-, 60-day and 3-month old male and female Wistar rats. Marked increases of basal (between 7 and 60 days of age) and of stimulated HACU levels via K+-depolarization (between 14 days and 3 months) but only a mild elevation in (3H)HC-3 binding (between 7 days and 3 months) associated with alterations in the binding site number were found. On the mature tissue, ethanol at high concentrations (5%) moderately inhibited the choline transport under basal conditions but totally eliminated depolarization effects. However, both age- and sex-dependent alterations in basal HACU mediated by high or low pharmacologically relevant alcohol concentrations (50-100 mM) were observed in the immature tissue. Namely, the dose- and incubation time-de

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurochemical Research

ISSN

0364-3190

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

3/4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

397-405

UT code for WoS article

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EID of the result in the Scopus database

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