Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F08%3A00000784" target="_blank" >RIV/00023752:_____/08:00000784 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk
Original language description
Objective: To identify specific treatment-emergent symptoms in response to antidepressant therapy in depression preceding bipolar disorder. Methods: Retrospective chart review of response to antidepressants in ?pre-bipolar? depression, compared to amatched unipolar sample. Results: Family history of completed suicide (p=0.0003) and bipolar disorder (p=0.004) were more common in the pre-bipolar subgroup. Earlier age of onset of diagnosed depression (p=0.005) as well as even earlier episodes of untreatedretrospectively diagnosed major depression (pb0.0001) were associated with a future bipolar course. The pre-bipolar group was less likely to respond to antidepressant treatment (p=0.009). Treatment-emergent ?mixed? symptoms (two or more symptoms of DSM IV mania, mood lability, irritability/rage with co-existing depression) and in particular, ?serious symptoms? (treatment emergent or increased agitation, rage or suicidality) occurred more commonly in the bipolar group. The two variables t
Czech name
Monotherapie antidepresivy u pre-bipolární deprese: prediktivní hodnota a rizika
Czech description
Toto je naturalistická studie o účincích antidepresiv u pacientů s depresí, předcházející diagnóze bipolární poruchy.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
—

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)