Distribution of PET radiotracer [11C](+)McN5652 (inhibitor of serotonin transporter) in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F09%3A00001002" target="_blank" >RIV/00023752:_____/09:00001002 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Distribution of PET radiotracer [11C](+)McN5652 (inhibitor of serotonin transporter) in rats
Original language description
Impaired serotonin transmission has been implicated in the pathophysiology of several psychiatric diseases. Drugs that inhibit serotonin transporter; SERT (citalopram, fluoxetin, etc) are important in treatment of depression, obsessive-compulsive behavior or anxiety. The most frequent radiotracer for SERT has been considered [11C](+)McN5652. Until today only few radiotracers for positron emission tomography (PET) imaging have obtained marketing authorization, none of them is SERT ligand. In this study we present whole body and brain biodistribution data of [11C](+)McN5652, which has been manufactured and released by NRI Rez plc. The accumulation of radioactivity in the cerebellum was lower in comparison with the SERT-rich regions. In brain, the highestradioactivity was found in frontal cortex, hemispheres and pont. The [11C](+)McN5652 is excreted by urine. In our study we show, that [11C](+)McN5652 is specific SERT radiotracer.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0517" target="_blank" >1M0517: Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychiatrie
ISSN
1211-7579
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
3
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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