Altered levels of circulating GABAergic 5?/?-reduced pregnane and androstane steroids in schizophrenic men

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F11%3A00001210" target="_blank" >RIV/00023752:_____/11:00001210 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1515/hmbci.2010.083" target="_blank" >http://dx.doi.org/10.1515/hmbci.2010.083</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/hmbci.2010.083" target="_blank" >10.1515/hmbci.2010.083</a>

Result language

angličtina

Original language name

Altered levels of circulating GABAergic 5?/?-reduced pregnane and androstane steroids in schizophrenic men

Original language description

The role of GABAergic pathways in the pathophysiology of schizophrenia is generally accepted. Therefore, the information concerning alterations of the steroid metabolome associated with the disease and/or its treatment is of interest with regard to the pathophysiology of the disease. Hence, we assessed 18 serum steroids and steroid polar conjugates in a group of drug-naive patients (13 adult men) and after 6-months therapy by atypical antipsychotics and age-matched controls (19 men) using gas chromatography-mass spectrometry analysis. This study, for the first time, demonstrates the altered circulating GABAergic steroids in schizophrenic men as well as the effect of the therapy with two types of atypical antipsychotics. The GABAergic androsterone (3?5?) and etiocholanolone (3?5?) are reduced in schizophrenic men but the therapy with atypical antipsychotics reinstates their levels. This reinstatement could be of importance when considering that the GABAergic substances generally improve

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/NS9835" target="_blank" >NS9835: The role of neuroactive steroids and other hormonal parameters in diagnostics and treatment of schizofrenia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hormone Molecular Biology and Clinical Investigation

ISSN

1868-1891

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

4

Pages from-to

227-230

UT code for WoS article

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EID of the result in the Scopus database

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