The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F12%3A43913807" target="_blank" >RIV/00023752:_____/12:43913807 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/12:10125525 RIV/60162694:G44__/12:43874722

Result on the web

<a href="http://dx.doi.org/10.1016/j.toxlet.2012.05.027" target="_blank" >http://dx.doi.org/10.1016/j.toxlet.2012.05.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.toxlet.2012.05.027" target="_blank" >10.1016/j.toxlet.2012.05.027</a>

Result language

angličtina

Original language name

The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers

Original language description

Organophosphorus poisoning manifests as a cholinergic syndrome due to an inhibition of acetylcholinesterase. It is treated symptomatically by anticholinergics and oxime reactivators are used as causal antidotes. Reactivators possess a complex mechanism of action and interact at various levels of the cholinergic transmission. The aim of this study was to investigate the effect of standard oxime reactivators (HI-6, obidoxime, trimedoxime, methoxime and pralidoxime) on the hemicholinium-3 sensitive carriers, which are involved in the high-affinity choline uptake (HACU) transport, a key regulatory step in the synthesis of acetylcholine. The activity of the carriers was estimated in vitro on hippocampal synaptosomes using the substrate (3H)-choline and thecompetitive inhibitor (3H)-hemicholinium-3. Furthermore, the effect of the reactivators on the fluidity of hippocampal membranes was assessed. All tested compounds, except methoxime, showed an acute inhibitory effect on the carriers, howe

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

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Volume of the periodical

212

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

315-319

UT code for WoS article

000307619100011

EID of the result in the Scopus database

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