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Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F12%3A43913810" target="_blank" >RIV/00023752:_____/12:43913810 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x" target="_blank" >http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x" target="_blank" >10.1111/j.1750-3639.2011.00525.x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease

  • Original language description

    Patological processing of tau protein during the formation and maturation of neurofibrillary tangles includes abnormal phosphorylation, conformational changes and truncation of the C-terminus. Abnormal phosphorylation and misfolding may serve as recognition signals for ubiquitin-targeting and proteosomal processing. Our findings indicate that tau protein in tangles may be dually subjected to both apoptotic and proteosomal processing. However, it appears that ubiquitin targeting of tau protein occurs attangles in the early and intermediate stages of the maturation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Brain Pathology

  • ISSN

    1015-6305

  • e-ISSN

  • Volume of the periodical

    22

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    240-250

  • UT code for WoS article

    000300834300010

  • EID of the result in the Scopus database