Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F12%3A43913810" target="_blank" >RIV/00023752:_____/12:43913810 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x" target="_blank" >http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x" target="_blank" >10.1111/j.1750-3639.2011.00525.x</a>
Alternative languages
Result language
angličtina
Original language name
Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease
Original language description
Patological processing of tau protein during the formation and maturation of neurofibrillary tangles includes abnormal phosphorylation, conformational changes and truncation of the C-terminus. Abnormal phosphorylation and misfolding may serve as recognition signals for ubiquitin-targeting and proteosomal processing. Our findings indicate that tau protein in tangles may be dually subjected to both apoptotic and proteosomal processing. However, it appears that ubiquitin targeting of tau protein occurs attangles in the early and intermediate stages of the maturation.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Pathology
ISSN
1015-6305
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
240-250
UT code for WoS article
000300834300010
EID of the result in the Scopus database
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